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Products Polyclonal Anti-FBLN2
| Catalogue number: | PA2159 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100?g/vial |
| Gene: | FBLN2 |
| Swiss prot: | P98095 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Fibulin-2, also known as FBLN2, is a protein that in humans is encoded by the FBLN2 gene. This gene encodes an extracellular matrix protein, which belongs to the fibulin family. By isotopic in situ hybridization, this gene is mapped to 3p25.1. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. It may play a role in testis development. Its binding to fibronectin and some other ligands is calcium dependent. |
| References: | 1. Ackerman, C., Locke, A. E., Feingold, E., Reshey, B., Espana, K., Thusberg, J., Mooney, S., Bean, L. J. H., Dooley, K. J., Cua, C. L., Reeves, R. H., Sherman, S. L., Maslen, C. L. An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects. Am. J. Hum. Genet. 91: 646-659, 2012. 2. Kuivaniemi, H., Marshall, A., Ganguly, A., Chu, M.-L., Abbott, W. M., Tromp, G. Fibulin-2 exhibits high degree of variability, but no structural changes concordant with abdominal aortic aneurysms. Europ. J. Hum. Genet. 6: 642-646, 1998. |
| Additional info: | A synthetic peptide corresponding to a sequence at the N-terminal of human FBLN2, different from the related mouse and rat sequences by two amino acids. |
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