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Products Polyclonal Anti-EPOR
| Catalogue number: | PA2032 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | EPOR |
| Swiss prot: | P19235 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | EPOR (Erythropoietin Receptor), is a protein that in humans is encoded by the EPOR gene. Jones et al. (1990) isolated the human homolog of the murine erythropoietin receptor (EPOR) from an erythroleukemia cell line and from fetal liver. Budarf et al. (1990) mapped the EPOR gene to human 19pter-q12 by somatic cell hybrid analysis. Akashi et al. (2000) reported the prospective identification, purification, and characterization, using cell surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloid lineages. The distinction between the common lymphoid progenitor and common myeloid progenitor is that the common lymphoid progenitor expresses IL7 receptor and does not express MPL, whereas the common myeloid progenitor does not express the IL7 receptor and expresses MPL. Becker et al. (2010) showed by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of the cell surface receptor are characteristic features of the EPO receptor. |
| References: | 1. Akashi, K., Traver, D., Miyamoto, T., Weissman, I. L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197, 2000. 2. Becker, V., Schilling, M., Bachmann, J., Baumann, U., Raue, A., Maiwald, T., Timmer, J., Klingmuller, U. Covering a broad dynamic range: information processing at the erythropoietin receptor. Science 328: 1404-1408, 2010. 3. Budarf, M., Huebner, K., Emanuel, B., Croce, C. M., Copeland, N. G., Jenkins, N. A., D'Andrea, A. D. Assignment of the erythropoietin receptor (EPOR) gene to mouse chromosome 9 and human chromosome 19. Genomics 8: 575-578, 1990. 4. Jones, S. S., D'Andrea, A. D., Haines, L. L., Wong, G. G. Human erythropoietin receptor: cloning, expression, and biologic characterization. Blood 76: 31-35, 1990. |
| Additional info: | A synthetic peptide corresponding to a sequence in the middle region of human EPOR, identical to the related mouse sequence, and different from the related rat sequence by three amino acids. |
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