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POLR3A (polymerase (RNA) III (DNA directed) polypeptide A, 155kDa) Blocking Peptide (the middle region of protein) (100ug)

POLR3A (polymerase (RNA) III (DNA directed) polypeptide A, 155kDa) Blocking Peptide (the middle region of protein) (100ug)

This is a synthetic peptide designed for use in combination with anti-POLR3A antibody (Catalogue #: ARP48725_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100 ug

Format

Lyophilized powder

Presku

AAP48725

Target

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3A is the largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.

Weight

156kDa

Gene Id

11128

Alternative Names

RPC1; RPC155; hRPC155

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