Supplier:
Aviva Systems Biology IncorporatedPML antibody - C-terminal region (ARP33048_P050)
Prices direct from Aviva Systems Biology Incorporated
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SPECIFICATIONS
Size
50ug
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat
Format
Lyophilized powder
Presku
ARP33048_P050
Target
PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus.
Weight
59kDa
Gene Id
5371
Alternative Names
MYL; PP8675; RNF71; TRIM19
SUPPLIER INFO
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