PLK1 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug)

Supplier: Aviva Systems Biology Incorporated

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Partial length PLK1 is expressed in E. coli.

Presku:	APL10459
Size:	200ug
Weight:	44
Gene:	5347
Target:	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
Alternative names:	PLK; STPK13