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PGA5 (2C1) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 252927

PGA5 (2C1) Antibody

PGA5 (Pepsinogen 5) is an endopeptidase precursor responsible for protein digestion in the stomach. Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor,Porcineepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows e, Xenopus/Amphibian,tremely broad specificity; although bonds involving phenylalanine and leucine are preferred,Mouse,any others are also cleaved to some e, Xenopus/Amphibian,tent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.\r

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SPECIFICATIONS

Catalog Number

252927

Size

0.1 ml

Applications

IHC

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of human PGA5 e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

P0DJD9

Clonality

2C1

Additional Info

Pepsin A-5; Pepsinogen-5; PGA5

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