PerCP/Cy5.5 anti-human FcepsilonRIalpha

High affinity IgE receptor (FcepsilonRI) plays a key role in IgE-mediated allergic immune response. FcepsilonRI is a tetrameric receptor complex, which is composed of one alpha-subunit (FcepsilonRIalpha), one beta-subunit, and two gamma-subunits. FcepsilonRIalpha directlybinds IgE with high affinity, while the beta- and gamma-chains are responsible for mediatingintracellular signals. FcepsilonRIalpha is a 50 kD transmembrane protein with Ig superfamily structure. It is primarily found on mast cells and basophils. Further studies have indicated that FcepsilonRIalpha is also expressed on many inflammatory cells including cutaneuos Langerhans cells, dendritic cells, monocytes of patients with allergic disorders, platelets, bronchial epithelial cells, eosinophils produced in hypereosinophilic syndrome, and neutrophils from allergy-induced asthma patients.

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SPECIFICATIONS

Catalog Number

334622

Size

100 tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Clone

AER-37 (CRA-1)

Gene Id

2205

Isotype

Mouse IgG2b, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * PerCP/Cy5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

Storage Temp

4 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

FceRIa, FceRI-a, FceRI-alpha, FceRI alpha, high affinity IgE receptor

Regulatory Status

RUO