PE anti-mouse lymphotoxin beta receptor (LTbetaR)

LTbetaR is a type I transmembrane glycoprotein and member of the TNF receptor superfamily. It is a 61 KDa receptor for the mouse LTalpha1beta2 and LIGHT. Northern blot analysis of tissues from adult mice showed that expression levels of LTbetaR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. It was reported that LTbetaR is expressed on stromal cells, monocytes, and certain embryonic epithelial layers. LTbetaR is involved in peripheral lymphoid tissue organogenesis and function. The LTalpha/LTbetaR receptor system may also have some function in early embryogenesis.