PE anti-mouse IFN-gamma R beta chain

IFN-gamma receptor beta chain is also known as IFN-gamma AF-1. This 60-65 kD class II cytokine receptor pairs with CDw119 to form the IFN-gamma receptor. CDw119 serves as the IFN-gamma-binding chain and associates with the IFN-gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN-gamma receptor alpha and beta chains must be species matched. The IFN-gamma receptor beta chain is expressed at low levels on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN-gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-gamma initiates and regulates a variety of immune responses.

Prices direct from BioLegend

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

113603

Size

50 microg

Applications

FC

Hosts

Ham

Reactivities

Mouse

Clone

MOB-47

Antigen

Mouse IFN-gammaR beta chain protein

Gene Id

15978

Isotype

Armenian Hamster IgG

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.2 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

IFN-gamma Receptor beta chain, IFN-gamma AF-1

Regulatory Status

RUO