PE anti-mouse DR3 (TNFRSF25)

DR3, also known as TNFRSF25, lymphocyte-associated receptor of death (LARD), WSL-1, TRAMP, TR3 and APO3, is a 55 kD glycoprotein belonging to the TNF receptor superfamily (TNFRSF). TNFSF25 is expressed at low level on CD4-positive, CD8-positive T cells and NKT cells. It has been shown to stimulate NF-kappaB activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domains containing adaptor proteins. Recently, it has been shown that TNFRSF25 is also expressed on Treg cells and regulates Treg proliferation.

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SPECIFICATIONS

Catalog Number

144406

Size

100 microg

Applications

FC

Reactivities

Mouse

Clone

4C12

Antigen

Mtnfr25-Ig fusion protein

Gene Id

85030

Isotype

Armenian Hamster IgG1, lambda

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.2 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

Apo-3, LARD, TNFRSF25, TNFR25, TRAMP, WSL-1, DR3, Apo3, TNFRSF 25, WSL1

Regulatory Status

RUO