PE anti-mouse CD262 (DR5, TRAIL-R2)

CD262 is a 55 kD protein also known as DR5, TRAIL-R2, Apo-2, TRICK2, and KILLER. DR5 is member 10B of the TNF receptor superfamily (TNFRSF10B), widely expressed in normal tissues and some tumor cell lines. The DR5 receptor binds to TRAIL and interacts with the cytoplasmic proteins TRADD and RIP. TRAIL binding to DR5 activates NF- kappaB and induces apoptosis. DR5 is induced by wild-type p53.

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SPECIFICATIONS

Catalog Number

119905

Size

50 microg

Applications

FC

Hosts

Ham

Reactivities

Mouse

Clone

MD5-1

Antigen

Mouse DR5-Ig fusion protein

Gene Id

21933

Isotype

Armenian Hamster IgG

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.2 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

DR5, TRAIL-R2, TRICK2, KILLER, TNFRS10B

Regulatory Status

RUO