PE anti-mouse CD124 (IL-4Ralpha)

CD124, a subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common gamma-chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13. A truncated form of IL-4Ralpha exists in soluble form in biological fluids. CD124 is expressed on mouse late precursors and mature B-cells, T-cells, monocytes, and has low expression on granulocytes. In B cells, CD124 can bind with IL-4 and IL-13 to regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for nonhematopoietic cell responses to IL-4 or IL-13.

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SPECIFICATIONS

Catalog Number

144804

Size

100 microg

Applications

FC

Hosts

Rat

Reactivities

Mouse

Clone

I015F8

Antigen

mIL4Ra Fc

Gene Id

4684

Isotype

Rat IgG2b, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.2 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

IL-4 receptor alpha subunit (IL-4Ra, IL4Ra), IL-4R (IL4R)

Regulatory Status

RUO