PE anti-human TCR Vbeta13.2

The Vbeta13.2 TCR is a variant of the TCR beta chain. It belongs to Ig superfamily and is expressed by a subset of peripheral blood T cells and some T cell clones. Vbeta expression in humans and mice has been used to study the effects of superantigens and also to examine the repertoires of T cells involved in inflammatory and autoimmune disease. It is reported that Vbeta13.2 TCRs possess very unusually long beta-chain CDR3 regions and are expressed on CTL specific for the immunodominant human HLA-B8–restricted HIV-1 nef epitope, FLKEKGGL (FL8). CTL expressing V beta13.2 TCRs tolerate naturally arising viral variants in the FL8 epitope that escape recognition by other CTL. The clone H132 recognizes the Vbeta13.2 allele product but does not react with the Vbeta13.1, 13.3, 13.5 and 13.6 allele products of the Vbeta13 subfamily.

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SPECIFICATIONS

Catalog Number

333108

Size

100 tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Clone

H132

Antigen

Human TCR Vbeta13.2 transfectant

Gene Id

6957

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microl to 5 microl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microl staining volume or per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.

Storage Temp

4 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

T cell receptor V beta 13.2

Regulatory Status

RUO