PE anti-human LAP (TGF-beta1)

TGF-beta1 (transforming growth factor beta1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-beta. TGF-beta is synthesized as a large protein precursor and then secreted as a complex of TGF-beta and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-beta to prevent its activity. TGF-beta requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-beta binds to the integrins alphavbeta1, alphavbeta6, alphavbeta8, and alpha8beta1 through RGD domain. TGF-beta plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-beta is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A recent study has shown that LAP is an activated Treg surface marker.

Prices direct from BioLegend

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

349604

Size

100 tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Clone

TW4-2F8

Antigen

LAP (TGF-beta)

Gene Id

7040

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Test size products are transitioning from 20 microl to 5 microl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 microl staining volume or per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.

Storage Temp

4 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-beta, TGF-B1

Regulatory Status

RUO