Supplier:
Aviva Systems Biology IncorporatedPcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor ) Blocking Peptide (the N terminal of Pcsk1n)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Hum, Rat
Format
Lyophilized powder
Presku
AAP59210
Target
Pcsk1n may function in the control of the neuroendocrine secretory pathway. It is proposed to be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Weight
28kDa
Gene Id
246333
Alternative Names
Saas
SUPPLIER INFO
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