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Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor ) Blocking Peptide (the N terminal of Pcsk1n)(100ug)

Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor ) Blocking Peptide (the N terminal of Pcsk1n)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Pcsk1n Antibody (ARP59210_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human, Rat
Presku: AAP59210
Size: 100ug
Weight: 28kDa
Gene: 246333
Format: Lyophilized powder
Target: Pcsk1n may function in the control of the neuroendocrine secretory pathway. It is proposed to be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Alternative names: Saas
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