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Products PCDHA11 (protocadherin alpha 11 ) Blocking Peptide (the N terminal of PCDHA11)(100ug)
| Reactivities: | Human |
| Presku: | AAP49346 |
| Size: | 100ug |
| Weight: | 85kDa |
| Gene: | The peptide is characterized by mass spectroscopy |
| Format: | Lyophilized powder |
| Target: | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. |
| Alternative names: | CNR7; CNRN7; CNRS7; CRNR7; PCDH-ALPHA11 |
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