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PCCA (Human) cDNA (1ug)

PCCA (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human PCCA is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-PCCA polyclonal antibody.
Presku: ANA10428
Size: 1ug
Gene: 5095
Target: The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.
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