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PAK6 Antibody (OAPB00181)

PAK6 Antibody (OAPB00181)

The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.

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SPECIFICATIONS

Size

0.1 mg

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Presku

OAPB00181

Target

a p21-activated kinase

Alternative Names

PAK6; p21-activated kinase 6

SUPPLIER INFO

Aviva Systems Biology Incorporated

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