Pacific Blue(TM) anti-mouse/human CD44

CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

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SPECIFICATIONS

Catalog Number

103020

Size

100 microg

Applications

FC

Hosts

Rat

Reactivities

Hum, Mouse

Clone

IM7

Antigen

Dexamethasone-induced myeloid leukemia M1 cells

Gene Id

12505,960

Isotype

Rat IgG2b, kappa

Clonality

Monoclonal

Dilutions

This CD44 reagent is developed for immunofluorescent staining for flow cytometric analysis, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is highly recommended that the reagent be titrated for optimal performance for each application.* Pacific Blue(TM) has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue(TM) conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome. ** Pacific Blue(TM) is a registered trademark of Molecular Probes, Inc. Pacific Blue(TM) dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The CD44 antibody solution should be stored undiluted at 4C, and protected from prolonged exposure to light. Do not freeze.

Alternative Names

Hermes, Pgp-1, H-CAM, HUTCH-1, ECMR III, gp85, Ly-24

Regulatory Status

RUO