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p16-INK4 Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250804

p16-INK4 Antibody

The cyclin-dependent kinase 4 inhibitor A (CDK4I or p16-INK4) acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6 and by subsequently inhibiting their interaction with cyclins D and retinoblastoma protein phosphorylation. Defects in p16-INK4 are involved in tumor formation in a wide range of tissues. These defects cause cutaneous malignant melanoma 2 (CMM2), familial atypical multiple mole melanoma-pancreatic carcinoma syndrome,Mouse,elanoma-astrocytoma syndrome and Li-Fraumeni syndrome.

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SPECIFICATIONS

Catalog Number

250804

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Ch/Bird, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human p16-INK4.

Isotype

Rabbit Ig

Accession

P42771

Additional Info

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; multiple tumor suppressor 1; MTS-1; CDKN2A; CDKN2; MTS1

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