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OX40 Ligand Recombinant Protein (0.002 mg)

OX40 Ligand Recombinant Protein (0.002 mg)

OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNgamma. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between

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SPECIFICATIONS

Size

0.002 mg

Presku

OPPB00219

Alternative Names

TNFSF4; OX40L; Gp34; CD252

SUPPLIER INFO

Aviva Systems Biology Incorporated

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