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OPTN (Human) cDNA (1ug)

OPTN (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human OPTN is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-OPTN polyclonal antibody.
Presku: ANA10583
Size: 1ug
Gene: 10133
Target: This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Alternative names: NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP
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