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OCLN (Human) cDNA (1ug)

OCLN (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human OCLN is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-OCLN polyclonal antibody.
Presku: ANA10491
Size: 1ug
Gene: 4950
Target: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
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