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Nucleophosmin (7H10) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 252594

Nucleophosmin (7H10) Antibody

Nucleophosmin (NPM) is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities . The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.

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SPECIFICATIONS

Catalog Number

252594

Size

0.1 ml

Applications

IF, IHC

Reactivities

Hum, Mouse

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of human NPM e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

P06748

Clonality

7H10B9

Additional Info

Nucleophosmin; NPM; Nucleolar phosphoprotein B23; Numatrin; Nucleolar protein NO38; NPM1; NPM

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