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NSMCE2 (non-SMC element 2, MMS21 homolog (S. cerevisiae)) Blocking Peptide (the middle region of protein) (100ug)

NSMCE2 (non-SMC element 2, MMS21 homolog (S. cerevisiae)) Blocking Peptide (the middle region of protein) (100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-NSMCE2 antibody (Catalogue #: ARP55690_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Presku: AAP55690
Size: 100 ug
Weight: 28kDa
Gene: 286053
Format: Lyophilized powder
Target: NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
Alternative names: C8orf36; FLJ32440; MMS21; NSE2
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