Presku: | AAP37876 |
Size: | 100 ug |
Weight: | 39kDa |
Gene: | 12355 |
Format: | Lyophilized powder |
Target: | NR1I3 mediates the induction of transcription of cytochrome P450 (CYP) genes by phenobarbital (PB) and PB-type inducers. NR1I3 activation induces hepatic expression of detoxification enzymes and transporters and increases liver size. NR1I3 can also regulate both liver homeostasis and tumorigenesis in response to xenobiotic stresses. |