

Supplier:
Aviva Systems Biology IncorporatedNR1I2 (nuclear receptor subfamily 1, group I, member 2) Blocking Peptide (100ug)
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SPECIFICATIONS
Size
100 ug
Format
Lyophilized powder
Presku
AAP39738
Target
NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain.The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described.
Weight
50kDa
Gene Id
8856
Alternative Names
BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Rat
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Bov
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum
Applications
WB
Hosts
Rabbit
Reactivities
Hum
Applications
WB
Hosts
Rabbit
Reactivities
Hum
Applications
WB
Hosts
Rabbit
Reactivities
Hum
Applications
WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Prc
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