NP antibody - middle region (ARP48474_P050)

This is a rabbit polyclonal antibody against NP. It was validated on Western Blot using a cell lysate as a positive control. Aviva Systems Biology strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (info@avivasysbio.com).

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SPECIFICATIONS

Size

50ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, ZF/Fish

Format

Lyophilized powder

Presku

ARP48474_P050

Target

Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. The specific function of NP is not yet known.This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Weight

32kDa

Gene Id

4860

Alternative Names

MGC117396; MGC125915; MGC125916; PNP; PRO1837; PUNP; NP