Notch 1 Antibody

Neurogenic locus notch homolog protein 1 (Notch 1) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), Notch 1 forms a transcriptional activator comple, Xenopus/Amphibian, with RBP-J kappa and activates genes of the enhancer of split locus. Notch 1 affects the implementation of differentiation,Porcineroliferation and apoptotic programs. Defects in Notch 1 are a cause of bicuspid aortic valve (BAV), a common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In e, Xenopus/Amphibian,treme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.