NME1 (NDP Kinase) plays a major role in the synthesis of nucleoside triphosphates other than ATP. It possesses nucleoside-diphosphate kinase and serine/threonine-specific protein kinase activity, in addition to geranyl and farnesyl pyrophosphate activity. NDP kinase is involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene e, Xenopus/Amphibian,pression. NDP kinase is required for neural development including neural patterning and cell fate determination.