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NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ) Blocking Peptide (the N terminal of NFKBIA)(100ug)

NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ) Blocking Peptide (the N terminal of NFKBIA)(100ug)

This is a synthetic peptide designed for use in combination with anti-NFKBIA Antibody (ARP30301_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100ug

Reactivities

Hum

Format

Lyophilized powder

Presku

AAP30301

Target

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Weight

35kDa

Gene Id

4792

Alternative Names

IKBA; MAD-3; NFKBI

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