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NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ) Blocking Peptide (the N terminal of NFKBIA)(100ug)

NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha ) Blocking Peptide (the N terminal of NFKBIA)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-NFKBIA Antibody (ARP30301_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP30301
Size: 100ug
Weight: 35kDa
Gene: 4792
Format: Lyophilized powder
Target: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Alternative names: IKBA; MAD-3; NFKBI
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