Presku: | AAP52524 |
Size: | 100 ug |
Weight: | 32kDa |
Gene: | 140825 |
Format: | Lyophilized powder |
Target: | NEURL2 contains 1 NHR (neuralized homology repeat) domain and 1 SOCS box domain. NEURL2 plays an important role in the process of myofiber differentiation and maturation. NEURL2 is the probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. NEURL2 probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, it controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma. |
Alternative names: | C20orf163, MGC125934, MGC125935, OZZ, Ozz-E3 |