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Nephrin Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 251170

Nephrin Antibody

Nephrin plays a role in the development or function of the kidney glomerular filtration barrier. Nephrin regulates glomerular vascular permeability, and anchors the podocyte slit diaphragm to the actin cytoskeleton. Nephrin interacts with CD2AP (via C-terminal domain). Nephrin plays a role in skeletal muscle formation through regulation of myoblast fusion. Defects in NPHS1 are the cause of nephrotic syndrome type 1 (NPHS1), also known as Finnish congenital nephrosis (CNF). NPHS1 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation.

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SPECIFICATIONS

Catalog Number

251170

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Prc, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human nephrin.

Isotype

Rabbit Ig

Accession

O60500

Additional Info

Nephrin; Renal glomerulus-specific cell adhesion receptor; NPHS1; NPHN

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