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NEK3 (Human) cDNA (1ug)

NEK3 (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human NEK3 is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-NEK3 polyclonal antibody.
Presku: ANA11267
Size: 1ug
Gene: 4752
Target: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Multiple transcript variants encoding different isoforms have been found for this gene.
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