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NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) Blocking Peptide (the middle region of protein) (100ug)

NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) Blocking Peptide (the middle region of protein) (100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-NEDD4L antibody (Catalogue #: ARP43192_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Presku: AAP43192
Size: 100 ug
Weight: 110kDa
Gene: 23327
Format: Lyophilized powder
Target: NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
Alternative names: FLJ33870; KIAA0439; RSP5; hNedd4-2
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