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NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) Blocking Peptide (the middle region of protein) (100ug)

NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) Blocking Peptide (the middle region of protein) (100ug)

This is a synthetic peptide designed for use in combination with anti-NEDD4L antibody (Catalogue #: ARP43192_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100 ug

Format

Lyophilized powder

Presku

AAP43192

Target

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

Weight

110kDa

Gene Id

23327

Alternative Names

FLJ33870; KIAA0439; RSP5; hNedd4-2

SUPPLIER INFO

Aviva Systems Biology Incorporated

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