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NALP5 Antibody (OAPB01168)

NALP5 Antibody (OAPB01168)

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Presku

OAPB01168

Target

NLR family pyrin domain containing 5

Alternative Names

NALP5; NLR family pyrin domain containing 5; NLRP5; MATER; PYRIN-containing APAF1-like protein 8; PYPAF8; CLR19.8; PAN11

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