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NALP4 Antibody (OAPB01167)

NALP4 Antibody (OAPB01167)

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappaB induction by TNF-alpha and IL-1beta, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappaB activity.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Presku

OAPB01167

Target

NLR family pyrin domain containing 4

Alternative Names

NALP4; NLR family pyrin domain containing 4; NLRP4; PYRIN-containing APAF1-like protein 4; PYPAF4; CLR19.5; PAN2; RNH2; CT58

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