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NALP3 Antibody (OAPB00980)

NALP3 Antibody (OAPB00980)

NALP3, a member of Nod-like receptors, has a crucial role in inflammation and immunity and may be a proximal sensor of cellular stress and danger signals. NALP3 forms a caspase-1 activating molecular complex termed the inflammasome. The inflammasome allows activation of IL-1beta, the key player of the inflammation and fever. NALP3 gene encodes a pyrin like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine rich repeat (LRR) motif. NALP3 protein interacts with apoptosis associated speck like protein containing a CARD and may function as an inducer of apoptosis and an activator of NF-kappaB signaling. Defects in NALP3 have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, IF, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Presku

OAPB00980

Target

LRR and PYD domains-containing protein 3

Alternative Names

NALP3; LRR and PYD domains-containing protein 3; CIAS1; FCAS; Cryopyrin

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