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Nae1 (NEDD8 activating enzyme E1 subunit 1 ) Blocking Peptide (the C terminal of Nae1)(100ug)

Nae1 (NEDD8 activating enzyme E1 subunit 1 ) Blocking Peptide (the C terminal of Nae1)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Nae1 Antibody (ARP59379_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human, Mouse
Presku: AAP59379
Size: 100ug
Weight: 60kDa
Gene: 234664
Format: Lyophilized powder
Target: Nae1 is a regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Alternative names: 59kDa; Appbp1
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