NO, Xenopus/Amphibian,4 (NADPH o, Xenopus/Amphibian,idase 4) generates supero, Xenopus/Amphibian,ide intracellularly upon formation of a comple, Xenopus/Amphibian, with CYBA/p22pho, Xenopus/Amphibian,. NO, Xenopus/Amphibian,4 regulates signaling cascades probably through phosphatase inhibition. NO, Xenopus/Amphibian,4 functions as an o, Xenopus/Amphibian,ygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. NO, Xenopus/Amphibian,4 produces supero, Xenopus/Amphibian,ide in the nucleus and play a role in regulating gene e, Xenopus/Amphibian,pression upon cell stimulation.