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MRGPRX2 (MAS-related GPR, member X2) Blocking Peptide (the middle region of MRGPRX2)(100ug)

MRGPRX2 (MAS-related GPR, member X2) Blocking Peptide (the middle region of MRGPRX2)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-MRGPRX2 Antibody (ARP59914_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP59914
Size: 100ug
Weight: 37kDa
Gene: 117194
Format: Lyophilized powder
Target: MRGPRX2 is an orphan receptor. It probably involved in the function of nociceptive neurons. It also may regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca2+ but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Alternative names: MRGX2
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