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MRGPRX1 (MAS-related GPR, member X1 ) Blocking Peptide (the C terminal of MRGPRX1)(100ug)

MRGPRX1 (MAS-related GPR, member X1 ) Blocking Peptide (the C terminal of MRGPRX1)(100ug)

This is a synthetic peptide designed for use in combination with anti-MRGPRX1 Antibody (ARP59925_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100ug

Reactivities

Hum

Format

Lyophilized powder

Presku

AAP59925

Target

MRGPRX1 is an orphan receptor. MRGPRX1 is probably involved in the function of nociceptive neurons. It may regulate nociceptor function and/or development, including the sensation or modulation of pain. MRGPRX1 is potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. MRGPRX1 is activated by the antimalarial drug, chloroquine and may mediate chloroquine-induced itch, in an histamine-independent manner.

Weight

36kDa

Gene Id

259249

Alternative Names

GPCR; MRGX1; SNSR4

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