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Mouse Anti- Mouse H- 2Kd/H- 2Dd- FITC(0.5 mg)

Mouse Anti- Mouse H- 2Kd/H- 2Dd- FITC(0.5 mg)

The пїЅclassicalпїЅ MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta2-microglobulin.3,4 These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells.5 MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.3,6 The monoclonal antibody 34-1-2S binds to a common determinant in the alpha3 domains of H-2Kd and H-2Dd in the presence or absence of beta2 microglobulin.7,8 It cross reacts with the alpha3 domain of H-2Kb.1,2

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SPECIFICATIONS

Size

0.5 mg

Hosts

Mouse

Clone

34- 1- 2S

Format

Fluorescein (FITC) Conjugate

Presku

OASB00712

Isotype

IgG2a

SUPPLIER INFO

Aviva Systems Biology Incorporated

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