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Mouse Anti- Mouse CD19- SPRD(0.1 mg)

Mouse Anti- Mouse CD19- SPRD(0.1 mg)

CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e., B220+/CD43+/HSa+) through fully differentiated B cell stages.1-7 Terminally differentiated plasma cells do not express CD19.1 In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation.3, 4 All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites.1, 7 Recent studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow.7

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SPECIFICATIONS

Size

0.1 mg

Hosts

Mouse

Clone

MB19- 1

Format

SpectralRed (SPRD) Conjugate

Presku

OASB00359

Isotype

IgA

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