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Mouse Anti- Human TRAIL- BIOT(0.5 mg)

Mouse Anti- Human TRAIL- BIOT(0.5 mg)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family of cytokines. This type II transmembrane protein is expressed by several cytotoxic immune cells, including natural killer cells and activated T cells, and is selective for tumorigenic and virally infected cells2,3. TRAIL can bind to DR4 and DR5 receptors on target cells which facilitates recruitment of numerous signaling proteins to form a death-inducing signaling complex. This signaling complex is then believed to propagate the apoptotic signal through the recruitment and activation of Caspase-84,5. Numerous studies have identified TRAIL as a potent apoptotic factor in a variety of human cancer cell lines, but this cytokine does not appear to affect normal cell lines6. Therefore, the selectivity and anti-tumorigenic properties of TRAIL make it an intriguing and potentially therapeutic agent in the treatment of cancer.

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SPECIFICATIONS

Size

0.5 mg

Hosts

Mouse

Clone

SB91a

Format

Biotin (BIOT) Conjugate

Presku

OASB01317

Isotype

IgG2b

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