Matrix metalloproteinases (MMPs) are a family of at least 20 structurally related, zinc-containing enzymes that have the ability to breakdown connective tissue. MMP-2 is also known as gelatinase A, 72 kDa gelatinase, type IV collagenase and TBE-1. MMP-2, along with MMP-9, belongs to the gelatinase group of MMP�s which have three repeats of a type II fibronectin domain inserted in the catalytic domain. MMP-2 has shown direct and indirect substrate specificity to collagens I, IV, V, VII, X and XIV, gelatin, elastin, laminin-1, laminin-5, myelin basic protein, MMP-1, MMP-9, and MMP-13. 1-15
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