Mouse Anti- Human IL- 33- UNLB(0.5mg)

Interleukin-33 (IL-33), also known as NF-HEV, is a 30kD protein and a recently identified member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells, but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways². IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-kappaB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5 and IL-13^3,4. In vivo administration of this cytokine in mice resulted in eosinophilia and splenomegaly, as well as induced severe pathological changes in the lungs, gastrointestinal tract and other mucosal organs^3,5,6.