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Mouse Anti- Human IL- 31- BIOT(0.1mg)

Mouse Anti- Human IL- 31- BIOT(0.1mg)

Interleukin-31 (IL-31) is a 24kD alpha-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells2. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response3,4. Over-expression has been linked to chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity and inflammatory bowel disease5-7.

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SPECIFICATIONS

Size

0.1mg

Hosts

Mouse

Clone

SB118b

Format

Biotin (BIOT) Conjugate

Presku

OASB01344

Isotype

IgG2b

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