Mouse Anti- Human CD51- UNLB(0.1 mg)

CD51 represents the 150 kDa integrin alpha_V chain that associates with integrin beta₃ (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils and platelets. CD51 is the most promiscuous integrin a subunit; it can form heterodimers with the beta₁ (CD29), beta₃ (CD61), beta₅, beta₆ and beta₈ subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins, including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31.^1-4