The CD35 antigen is composed of four different allotypes having different molecular weights (A (or F) - 160 kDa, B (or S) - 190 kDa, C - 220 kDa, and D - 250 kDa). It is the receptor for C3b and is found on B cells, a subset of T cells, monocytes, neutrophils, follicular dendritic cells, erythrocytes and kidney glomelular podocytes. CD35 mediates neutrophil and monocyte phagocytosis of particles coated with C3b and/or C4b. This interaction also enhances phagocytosis mediated by the Fc receptors.1-5
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